反应详情

First, 2.1 grams (0.01 mole) of the intermediate of Example I, 2.3 grams (0.011 mole) of 2-(4-chlorophenyl)3-methyl butyric acid, 1.0 grams (0.01 mole) of triethylamine, and 100 milliliters of methylethylketone were combined and heated under reflux for 2 hours. The mixture was then cooled and poured into 200 milliliters of benzene. The benzene mixture was then washed in turn with 100 milliliters of H2O, 100 milliliters of 5% K2CO3 solution, and 100 milliliters of H2O. The benzene phase was then dried with MgSO4 and evaporated in vacuo to yield 3.0 grams (78% of theory) of the desired product. nD30 1.5210.

1. temperatureheated
2. temperatureunder reflux for 2 hours
3. temperatureThe mixture was then cooled
4. washThe benzene mixture was then washed
5. dry with materialThe benzene phase was then dried with MgSO4
6. customevaporated in vacuo