反应详情

温度

25 °C

2-Methyl-2-phenyl-5-hydroxy-6,7-dichloro-1-indanone (4.61 g., 0.015 mole), chloroacetonitrile (1.13 g., 0.015 mole), potassium carbonate (2.08 g., 0.015 mole), potassium iodide (0.25 g., 0.0015 mole) and acetone (75 ml.) are heated at reflux for 23 hours. The reaction mixture is cooled to 25° C. and concentrated to dryness in vacuo to give an oily residue which on trituration with water gives 5.12 g. of (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetonitrile which melts at 163°-165° C. on crystallization from cyclohexane:benzene, 5:1.

1. temperatureat reflux for 23 hours
2. concentrationconcentrated to dryness in vacuo
3. customto give an oily residue which on trituration with water
4. customgives 5.12 g
5. customof (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetonitrile which melts at 163°-165° C. on crystallization from cyclohexane