反应详情

A mixture of 258 g (1.27 mol) of 2-(3-chloropropyl)benzyl chloride, 2, 140 g (1.4 mol) of 2,4-pentanedione, 6, 175 g (1.27 mol) potassium carbonate, and 700 ml of absolute ethanol was stirred at reflux for 18 hours. Evaporation of the alcohol gave a residue which was partitioned between ether and water. The organic phase was dried over anhydrous MgSO4, concentrated and the residue distilled to give the chloro ketone 7, 218 g, bp 123°-127° C/0.2 mm.

1. temperatureat reflux for 18 hours
2. customEvaporation of the alcohol
3. customgave a residue which
4. customwas partitioned between ether and water
5. dry with materialThe organic phase was dried over anhydrous MgSO4
6. concentrationconcentrated
7. distillationthe residue distilled