反应详情

2-Ethyl-hexanoylchloride (0.057 mol, Sigma-Aldrich Israel Ltd.), dissolved in dry acetonitrile (50 ml), was slowly added to a dry, boiling solution of urea (0.14 mole) in acetonitrile (100 ml) and allowed to reflux for 2 hours. Thereafter the organic solvent was evaporated under reduced pressure and the product was dissolved in ethyl acetate (100 ml) and washed three times with 20 ml of distilled water. The organic fraction was dried over MgSO4, filtered and evaporated under reduced pressure. The product was purified by crystallization from ethyl acetate.

1. additionwas slowly added to a dry
2. temperatureto reflux for 2 hours
3. customThereafter the organic solvent was evaporated under reduced pressure
4. dissolutionthe product was dissolved in ethyl acetate (100 ml)
5. washwashed three times with 20 ml of distilled water
6. dry with materialThe organic fraction was dried over MgSO4
7. filtrationfiltered
8. customevaporated under reduced pressure
9. customThe product was purified by crystallization from ethyl acetate