Sodium Hydroxide → HCID 86735785, compound

HRID 839781Notes

Reaction equation

HRID 839781 reaction equation
[OH-:1].[Na+].[F:3][C:4]([F:34])([F:33])[CH2:5][O:6][C:7]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[CH:23][C:8]=1[C:9]([N:11]([CH2:19][CH2:20][CH2:21][CH3:22])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[O:10]>>[C:28]([OH:1])(=[O:27])[CH3:29].[F:34][C:4]([F:3])([F:33])[CH2:5][O:6][C:7]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[CH:23][C:8]=1[C:9]([N:11]([CH2:19][CH2:20][CH2:21][CH3:22])[CH2:12][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][NH:14]1)=[O:10]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20321976N-Butyl-N-[(pyridin-2-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Product 1

HCID 86735785HCID 86735785, compound

Procedure

Using the method of Example 12 except omitting the treatment with sodium hydroxide, 4.64 g. of 2,5-bis(2,2,2-trifluoroethoxy)-N-n-butyl-N-(2-pyridylmethyl)benzamide is reduced to provide white solid product, 2,5-bis(2,2,2-trifluoroethoxy)-N-n-butyl-N-(2-piperidylmethyl)benzamide acetate, m.p. 119°-120° C.

Sources & evidence

ORD record
ord-05fcbf3093984a8684b5fdcd504928aa
Source dataset
uspto-grants-1978_06
Patent number
US04097481

Reaction notes

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