Triethylamine → HCID 20322094, compound

HRID 839814Notes

Reaction equation

HRID 839814 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].Br[CH2:11][CH:12]1[O:17][CH2:16][CH2:15][CH2:14][O:13]1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:11][CH:12]1[O:17][CH2:16][CH2:15][CH2:14][O:13]1)[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 695242,2-DiethoxyethylamineHCID 3036832-bromomethyl-1,3-dioxane

Product 1

HCID 20322094HCID 20322094, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2,2-Diethoxyethylamine (23.3 grams), 2-bromomethyl-1,3-dioxane (29.2 grams), triethylamine (25 ml) and toluene (150 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux overnight. After this time the mixture is cooled and filtered. The filtrate is then distilled under reduced pressure to yield the desired product N-(2,2-diethoxyethyl)-N-(1,3-dioxan-2-ylmethyl)amine.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux overnight
  5. temperatureAfter this time the mixture is cooled
  6. filtrationfiltered
  7. distillationThe filtrate is then distilled under reduced pressure

Sources & evidence

ORD record
ord-ce262f535bd5422b949724e8ffee2c25
Source dataset
uspto-grants-1978_06
Patent number
US04097491

Reaction notes

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