Triethylamine → HCID 20322099, compound

HRID 839818Notes

Reaction equation

HRID 839818 reaction equation
[CH3:1][O:2][CH:3]([O:6][CH2:7][CH3:8])[CH2:4][NH2:5].Br[CH2:10][CH:11]1[O:16][CH2:15][CH2:14][CH2:13][O:12]1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:15][O:16][CH:11]([O:12][CH2:13][CH3:14])[CH2:10][NH:5][CH2:4][CH:3]1[O:2][CH2:1][CH2:8][CH2:7][O:6]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 3036832-bromomethyl-1,3-dioxaneHCID 22766278HCID 22766278, compound

Product 1

HCID 20322099HCID 20322099, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-Methoxy-2-ethoxyethylamine (0.11 mole), 2-bromomethyl-1,3-dioxane (0.1 mole), triethylamine (20 ml) and toluene (150 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction is heated at reflux for a period of about 12 hours. After this time the reaction mixture is allowed to cool to room temperature and is filtered. The reaction mixture is then stripped of solvent and unreacted starting materials under reduced pressure to yield the desired product N-(2-methoxy-2-ethoxyethyl)-N-(1,3-dioxan-2-ylmethyl)amine.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction is heated
  4. temperatureat reflux for a period of about 12 hours
  5. filtrationis filtered

Sources & evidence

ORD record
ord-c9b116a5d4b644b2bf48d3fc72a38d25
Source dataset
uspto-grants-1978_06
Patent number
US04097491

Reaction notes

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