Hydrochloric Acid → HCID 86735805, compound

HRID 839893Notes

Reaction equation

HRID 839893 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]2=[CH:11][CH:10]=1)=[O:8].Cl>C(O)CC(C)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([O:19][CH2:14][CH2:15][CH:16]([CH3:17])[CH3:12])=[O:18])[C:12]2=[CH:11][CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70480598HCID 70480598, compound

Product 1

HCID 86735805HCID 86735805, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

A solution of 300 mg. of 5-(N-methyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of isoamyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue purified by chromatography on alumina, to yield isoamyl 5-(N-methyl-2-pyrroyl)-1,2-dihydro-3H-pyrrolo[ 1,2-a]pyrrole-1-carboxylate.

Workup

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue purified by chromatography on alumina

Sources & evidence

ORD record
ord-eeb3b2976ee24e338013e09687f1ea72
Source dataset
uspto-grants-1978_06
Patent number
US04097579

Reaction notes

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