Potassium Cyanide → HCID 22763976, compound

HRID 839896Notes

Reaction equation

HRID 839896 reaction equation
[C-:1]#[N:2].[K+].Br[CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[O:12][C:11]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[CH:10][C:9]2=[O:23]>O.C(O)C>[C:1]([CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[O:12][C:11]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[CH:10][C:9]2=[O:23])#[N:2]

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 22763998HCID 22763998, compound

Product 1

HCID 22763976HCID 22763976, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

3.2 g (0.05 mole) of potassium cyanide dissolved in 50 ml of water is placed in a reaction vessel. The solution is heated to 60° C and a solution of 8.3 g (0.023 mole) of 6-bromomethyl-2-(p-chlorophenyl)chromone in 1600 ml of ethanol is added in four portions, one every 20 minutes. Once the addition is complete the mixture is refluxed for 3 hours, evaporated to dryness and dissolved in water. The solid is filtered off and recrystallised from alcohol.

Workup

  1. customis placed in a reaction vessel
  2. additionOnce the addition
  3. temperatureis refluxed for 3 hours
  4. customevaporated to dryness
  5. dissolutiondissolved in water
  6. filtrationThe solid is filtered off
  7. customrecrystallised from alcohol

Sources & evidence

ORD record
ord-28f804b3306345a1840b847da7a5685a
Source dataset
uspto-grants-1978_06
Patent number
US04097582

Reaction notes

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