Triethylamine → HCID 178472727, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][NH:6][CH2:7][CH2:8][O:9][CH3:10])[CH3:2].C(N(CC)CC)C.[N:19]#[N:20].[CH:21]1[C:29]2[C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[S:26][C:25]=2[CH:24]=[CH:23][C:22]=1[S:34]([NH:37][C@H:38]([C:46](Cl)=[O:47])[CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:45])[NH2:44])(=[O:36])=[O:35]>C(Cl)(Cl)Cl>[N:19]#[N:20].[CH2:1]([O:3][C:4](=[O:11])[CH2:5][N:6]([C:46](=[O:47])[C@H:38]([CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:44])[NH2:45])[NH:37][S:34]([C:22]1[CH:23]=[CH:24][C:25]2[S:26][C:27]3[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=3[C:29]=2[CH:21]=1)(=[O:35])=[O:36])[CH2:7][CH2:8][O:9][CH3:10])[CH3:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of 2.42 g of N-(2-methoxyethyl) glycine ethyl ester and 4.0 ml of triethylamine in 50 ml of chloroform, which was cooled in an ice-salt bath, was added in portions N2 -(2-dibenzothienylsulfonyl)-L-arginyl chloride obtained above. The reaction mixture was stirred overnight at room temperature. At the end of this period, 50 ml of chloroform was added and the chloroform solution was washed twice with 25 ml of saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated in vacuo. The oily residue was washed with ethyl ether to give 5.5 g of powdery N2 -(2-dibenzothienylsulfonyl)-L-arginyl-N-(2-methoxyethyl)glycine ethyl ester
Workup
- customobtained above
- washthe chloroform solution was washed twice with 25 ml of saturated sodium chloride solution
- dry with materialdried over anhydrous sodium sulfate
- customevaporated in vacuo
- washThe oily residue was washed with ethyl ether
Sources & evidence
- ORD record
- ord-6c6cfef680654760a3b4930e68f52a98
- Source dataset
- uspto-grants-1978_06
- Patent number
- US04097591
Reaction notes
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