反应详情

温度

60 °C

To a mixture of 20 g. of sodium hydroxide and 400 ml. of methanol are added 24.5 g. of methyl 6-methoxy-2-naphthyl-α-methylacetate. The resulting reaction mixture is heated to 60° C for 5 hours. The cooled mixture is neutralized by the addition of aqueous 1N hydrochloric acid and extracted with methylene chloride. The extracts are combined, washed with water to neutrality, dried over sodium sulfate, filtered, and evaporated to give 6-methoxy-2-naphthyl-α-methylacetic acid.

1. additionTo a mixture of 20 g
2. customThe resulting reaction mixture
3. extractionextracted with methylene chloride
4. washwashed with water to neutrality
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated