HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-Iodo-1-octyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Oct-7-yn-1-yl 4-methylbenzene-1-sulfonate | HCID 10779145 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-Iodo-1-octyne | HCID 22621556 | 94.2% |
Reaction Steps
A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365350B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-15557948ec354671bcc50160cab9f5a5 |
| Source note | uspto-grants-2002_04 |