反应详情

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

1. customto react for four hours
2. temperatureunder reflux
3. temperatureAfter cooling
4. customthe precipitates were removed by filtration
5. concentrationthe filtrate was concentrated
6. customThe resulting residue was purified by silica gel column chromatography (eluent; hexane)