(R)-1,2-Epoxypropane → HCID 69836067, compound

HRID 840108Notes

Reaction equation

HRID 840108 reaction equation
[NH:1]1[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[CH:3]=[CH:2]1)[CH:10]=[N:9][CH:8]=[CH:7]3.[CH2:14]1[O:17][C@@H:15]1[CH3:16]>>[N:1]1([CH2:14][C@H:15]([OH:17])[CH3:16])[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[CH:3]=[CH:2]1)[CH:10]=[N:9][CH:8]=[CH:7]3

Participants

3

Reactant 2

HCID 146261(R)-1,2-EpoxypropaneHCID 132624211H-Pyrrolo[2,3-f]isoquinoline

Product 1

HCID 69836067HCID 69836067, compound

Procedure

(R)-1-(1H-Pyrrolo[2,3-f]isoquinolin-1-yl)-2-propanol was prepared according to the method described in Example 1 using 1H-pyrrolo[2,3-f]isoquinoline (Farmaco, 1989, 44(12), 1141-55) and (R)-propylene oxide to give 0.77 g (71%) of the product as a white solid. A recrystallised sample [cyclohexane-ethanol (4:1)] gave mp 169-170° C.; Found: C, 74.09; H, 6.28; N, 12.27%. C14H14N2O requires C, 74.31; H, 6.24; N, 12.37%.

Sources & evidence

ORD record
ord-9ffc3e1918064dd5b3edc2f02c92a104
Source dataset
uspto-grants-2002_04
Patent number
US06365598B1

Reaction notes

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