Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 840113Notes

Reaction equation

HRID 840113 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754, compound

Product 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Procedure

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).

Workup

  1. temperatureat reflux for 30 hours
  2. filtrationthe mixture was filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

Sources & evidence

ORD record
ord-9b1a44af70bc4808a08b0b67da894c49
Source dataset
uspto-grants-2002_04
Patent number
US06365591B1

Reaction notes

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