反应详情

温度

22.5 °C

A mixture of 0.66 g of Compound 5A and 0.07 g of Raney-Nickel in 20 mL of ethyl acetate was stirred for 14 hours at 20-25° C. The organic layer was separated and the mixture extracted with 2×40 mL of ethyl acetate. The combined organic layers were washed with 20 mL of brine, dried over sodium sulphate and evaporated to dryness in vacuo to afford 0.52 g (90.6%) of Compound 5B as an orange oil.

1. customThe organic layer was separated
2. extractionthe mixture extracted with 2×40 mL of ethyl acetate
3. washThe combined organic layers were washed with 20 mL of brine
4. dry with materialdried over sodium sulphate
5. customevaporated to dryness in vacuo