HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-{4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazin-1-yl}propylamine → 3-Phenyl-N-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]isoxazole-4-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-{4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazin-1-yl}propylamine | HCID 10567490 | — |
| Edukt | 3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid | HCID 23447885 | — |
| Edukt | 1-(3-Aminopropyl)-4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine | HCID 23447911 | — |
| Produkt | 3-Phenyl-N-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]isoxazole-4-carboxamide | HCID 23447905 | 88% |
Reaktionsschritte
The title compound was prepared according to the procedure described in Example 8, but substituting compound 15B for Compound 8D and Compound 12B for Compound 8B. Purification by flash chromatography (ethyl acetate-2 N ammonia in methanol 95:5) yielded the title product (88%). M.p. 94.5-95.6° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06365591B1 |
| Quelldatensatz | uspto-grants-2002_04 |
| ORD ID | ord-850b8ee885204d4f80841c889eb9ca48 |
| Quellennotiz | uspto-grants-2002_04 |