1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 23447914, compound

HRID 840128Notes

Reaction equation

HRID 840128 reaction equation
Cl[CH2:2][CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:10][O:11][C:12]=1[CH3:13])=[O:7].[F:20][C:21]([F:37])([F:36])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.O[C:39]1C=CC(Cl)=CC=1N1CCNCC1>C(OCC)(=O)C>[CH2:13]([C:12]1[O:11][N:10]=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]=1[C:6]([NH:5][CH2:4][CH2:3][CH2:2][N:33]1[CH2:34][CH2:35][N:30]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[O:23][CH2:22][C:21]([F:20])([F:36])[F:37])[CH2:31][CH2:32]1)=[O:7])[CH3:39]

Participants

5

Reactant 3

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 23447862HCID 23447862, compoundHCID 234478814-Chloro-2-(1-piperazinyl)phenol

Product 1

HCID 23447914HCID 23447914, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was obtained following the procedure described in Example 2 but substituting Compound 19A for Compound 2B and 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine for 1-(2-hydroxy-5-chlorophenyl)piperazine. The crude was taken up with ethyl acetate and purified by flash chromatography eluting (ethyl acetate-2 N ammonia in methanol 98:2) to afford the title compound (54%). M.p. 102-104° C.

Workup

  1. custompurified by flash chromatography
  2. washeluting (ethyl acetate-2 N ammonia in methanol 98:2)

Sources & evidence

ORD record
ord-19de07ad81ce48b585ccc0b51a3ecfc5
Source dataset
uspto-grants-2002_04
Patent number
US06365591B1

Reaction notes

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