4-Chloro-2-toluidine → 1-(4-Chloro-o-tolyl)piperazine

HRID 840133Notes

Reaction equation

HRID 840133 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1.[Cl:15]C1C=CC(N)=C(C)C=1>>[Cl:15][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([CH3:14])[CH:3]=1

Participants

3

Reactant 2

HCID 72514-Chloro-2-toluidineHCID 184230721-(4-Fluoro-2-methylphenyl)piperazine

Product 1

HCID 1008521-(4-Chloro-o-tolyl)piperazineYield 73%

Procedure

The title compound was prepared following the method described for the Compound 31A of Example 31 but starting from 4-chloro-2-methylaniline instead of 4-fluoro-2-methylaniline. Purification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5) afforded the title compound (73%) as an oil.

Workup

  1. customThe title compound was prepared
  2. customPurification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5)

Sources & evidence

ORD record
ord-9e21c63ea0f042a3b1f696420bad37f9
Source dataset
uspto-grants-2002_04
Patent number
US06365591B1

Reaction notes

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