HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-toluidine → 1-(4-Chloro-o-tolyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-toluidine | HCID 7251 | — |
| Reactant | 1-(4-Fluoro-2-methylphenyl)piperazine | HCID 18423072 | — |
| Product | 1-(4-Chloro-o-tolyl)piperazine | HCID 100852 | 73% |
Reaction Steps
The title compound was prepared following the method described for the Compound 31A of Example 31 but starting from 4-chloro-2-methylaniline instead of 4-fluoro-2-methylaniline. Purification by flash chromatography (chloroform-2N ammonia in methanol 100:3 to 100:5) afforded the title compound (73%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365591B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-9e21c63ea0f042a3b1f696420bad37f9 |
| Source note | uspto-grants-2002_04 |