6-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-4-(3-methoxyphenyl)-2(1h)-quinolinone → 6-(4-Chlorobenzoyl)-4-(3-methoxyphenyl)-2(1h)-quinolinone

HRID 840157Notes

Reaction equation

HRID 840157 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[NH:19][C:18](=[O:23])[CH:17]=[C:16]4[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)OCC[O:9]2)=[CH:4][CH:3]=1>Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH:17]=[C:16]3[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 227143486-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-4-(3-methoxyphenyl)-2(1h)-quinolinone

Product 1

HCID 227143706-(4-Chlorobenzoyl)-4-(3-methoxyphenyl)-2(1h)-quinolinoneYield 94%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A mixture of interm. (5-e) (43 g) in HCl (3N, 400 ml) and methanol (150 ml) was stirred and refluxed overnight. The mixture was cooled and filtered off. The precipitate was washed with water and diethyl ether and dried. The product was used without further purification, yielding 27 g (94%) of 6-(4-chlorobenzoyl)-4-(3-methoxyphenyl)-2(1H)-quinolinone (interm. 5-f).

Workup

  1. additionA mixture of interm
  2. temperaturerefluxed overnight
  3. temperatureThe mixture was cooled
  4. filtrationfiltered off
  5. washThe precipitate was washed with water and diethyl ether
  6. customdried
  7. customThe product was used without further purification

Sources & evidence

ORD record
ord-a63fc3ee3e054e22af50068177b11d29
Source dataset
uspto-grants-2002_04
Patent number
US06365600B1

Reaction notes

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