HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 5-Amino-1-(2-fluoroethyl)-1,3-dihydro-2h-2,1-benzisothiazole-2,2-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-(2-Fluoroethyl)-5-nitro-1,3-dihydro-2h-2,1-benzisothiazole-2,2-dione | HCID 22622762 | — |
| Solvent | Palladium | HCID 23938 | — |
| Product | 5-Amino-1-(2-fluoroethyl)-1,3-dihydro-2h-2,1-benzisothiazole-2,2-dione | HCID 22622761 | 99.5% |
Reaction Steps
The product of Step 1 (1.25 g, 4.8 mmol) is dissolved into EtOAc (30 mL) in a Parr bottle and 10% Pd/C (100 mg) added under nitrogen. The mixture is hydrogenated on a Parr apparatus for 4 hrs at 40 psi. Filtration and evaporation of solvent gave a solid (1.1 g, 99%). Mp 119-21° C. HRMS (FAB) calcd for C9H11FN2O2S +H1 231.0603, found 231.0610.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365612B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-32169b0b99264d23a5f0d0c25e42599c |
| Source note | uspto-grants-2002_04 |