反应详情

To a solution of the compound obtained from step h above (0.75 g) in tetrahydrofuran (15 mL), lithium aluminum hydride (0.096 g) was added at 0° C. The resulting mixture was stirred for 3 hours at same temperature, and a saturated solution of ammonium chloride was then added. The reaction mixture was then filtered through silica gel (100 to 200 mesh) and concentrated. Ethyl acetate and water were added to the resulting residue. The organic layer was separated, washed with water and brine, dried over anhydrous sodium sulphate, filtered, and concentrated under reduced pressure to afford the title compound (0.65 g).

1. filtrationThe reaction mixture was then filtered through silica gel (100 to 200 mesh)
2. concentrationconcentrated
3. additionEthyl acetate and water were added to the resulting residue
4. customThe organic layer was separated
5. washwashed with water and brine
6. dry with materialdried over anhydrous sodium sulphate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure