HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl mercaptan → 4-[8-Chloro-5,6-Dihydro-4-(Phenylmethylthio)-11H-Benzo[5,6]Cyclohepta[1,2-b]Pyridin-11-Ylidene]-1-(3-Pyridinylacetyl)-Piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl mercaptan | HCID 7509 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-[4,8-Dichloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-b]Pyridin-11-Ylidene]-1-(3-Pyridinylacetyl)-Piperidine | HCID 22621955 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[8-Chloro-5,6-Dihydro-4-(Phenylmethylthio)-11H-Benzo[5,6]Cyclohepta[1,2-b]Pyridin-11-Ylidene]-1-(3-Pyridinylacetyl)-Piperidine | HCID 22621980 | 8% |
Reaction Steps
A mixture of the title compound from Example 250 (0.25 grams), sodium hydride (0.11 grams, 60% in mineral oil), benzyl mercaptan (0.13 mL) and anhydrous DMF (15 mL) was stirred while being irradiated with a 200 W lamp for 10 days. Isolation and purification as in Example 257 provided the title compound (0.02 grams, 8%, MH+ 552).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365588B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-c4292c3538224eb8b9f4694bf54061e0 |
| Source note | uspto-grants-2002_04 |