HRID840277

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7509

Benzenemethanethiol

C7H8S

HCID24758

Sodium hydride

HNa

结构：O=C(Cc1cccnc1)N1CCC(=C2c3ccc(Cl)cc3CCc3c(Cl)ccnc32)CC1

HCID22621955

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1cccnc1)N1CCC(=C2c3ccc(Cl)cc3CCc3c(SCc4ccccc4)ccnc32)CC1

HCID22621980

未命名化合物

收率 8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of the title compound from Example 250 (0.25 grams), sodium hydride (0.11 grams, 60% in mineral oil), benzyl mercaptan (0.13 mL) and anhydrous DMF (15 mL) was stirred while being irradiated with a 200 W lamp for 10 days. Isolation and purification as in Example 257 provided the title compound (0.02 grams, 8%, MH+ 552).

WORKUP

后处理

customwhile being irradiated with a 200 W lamp for 10 days
customIsolation and purification as in Example 257

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c4292c3538224eb8b9f4694bf54061e0
来源数据集: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06365588B1
来源说明: uspto-grants-2002_04

反应 SMILES

Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.[H-].[Na+].[CH2:35]([SH:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>CN(C=O)C>[Cl:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:4]3=[N:5][CH:6]=[CH:7][C:2]([S:42][CH2:35][C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[C:3]3[CH2:12][CH2:11][C:10]=2[CH:13]=1