反应详情

温度

170 °C

6-Chloronicotinic acid (100 g, 0.63 mol) was treated with ethylamine (70% in water, 500 ml). The reaction was sealed in an autoclave and heated to 170 ° C. for 6 hours. The reaction mixture was evaporated, partially neutralized with concentrated HCl and the pH adjusted to pH 5 with glacial acetic acid. The solid product was filtered off and dried in vacuo for 18 hours to give 6-(ethylamino)nicotinic acid (87.8 g, 84%).

1. customThe reaction was sealed in an autoclave
2. customThe reaction mixture was evaporated
3. filtrationThe solid product was filtered off
4. customdried in vacuo for 18 hours