反应详情

温度

-20 °C

A 4-necked 5-L flask, equipped with a mechanical stirrer, a thermometer, and an additional funnel, is charged with methyl isobutyl ketone (1500 g), 1,1-dichloro-2,2-bis(4-hydroxyphenyl)ethene (320 g), and cyanogen bromide (270 g). The resulting solution is cooled to −20° C. with a dry ice/acetone bath. To the stirring solution, triethylamine (240 g) in the additional funnel is added dropwise. The reaction temperature is maintained below −20° C. After the addition, the resulting mixture is allowed to warm up to 0° C. and quenched with dilute HCl aqueous solution. The organic layer is washed further with water a few times and concentrated under vacuum to afford 370 g of amber liquid, which solidifies as light tan color solids.

1. customA 4-necked 5-L flask, equipped with a mechanical stirrer
2. temperatureThe reaction temperature is maintained below −20° C
3. additionAfter the addition
4. temperatureto warm up to 0° C.
5. customquenched with dilute HCl aqueous solution
6. washThe organic layer is washed further with water a few times
7. concentrationconcentrated under vacuum