Acetic Acid → HCID 22623287, compound

HRID 840359Notes

Reaction equation

HRID 840359 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[C:10]1(=O)[O:15][C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12.C(O)(=O)C>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]2[C:13](=[O:14])[C:12]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]3[C:10]2=[O:15])=[C:4]([F:9])[CH:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6811Phthalic AnhydrideHCID 938984-Chloro-2-fluoroaniline

Product 1

HCID 22623287HCID 22623287, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 29.1 g of 4-chloro-2-fluoroaniline, 29.6 g of phthalic anhydride, and 150 ml of acetic acid was heated under reflux for 2 hours under stirring. After allowing the mixture to cool, the reaction mixture was poured into water, and the precipitated solid was collected by filtration. The resulting solid was washed with water and dried under reduced pressure to afford 50.9 g of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. temperatureto cool
  4. filtrationthe precipitated solid was collected by filtration
  5. washThe resulting solid was washed with water
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-65dc6ffa2fb4406aa0cb3b40bdd2e386
Source dataset
uspto-grants-2002_04
Patent number
US06365753B1

Reaction notes

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