3-Nitro-5,6,7,8-tetrahydronaphthalen-2-ol → 2-(5,6,7,8-Tetrahydro-3-nitro-2-naphthoxy)-propionic acid ethyl ester

HRID 840364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 840364
[N+:1]([C:4]1[C:5]([OH:14])=[CH:6][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=1)([O-:3])=[O:2].[CH3:15]CCCCC.[C:21]([O:24][CH2:25][CH3:26])(=[O:23])[CH3:22]>>[CH2:25]([O:24][C:21](=[O:23])[CH:22]([O:14][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=1)[CH3:15])[CH3:26]

Komponenten

3

Edukt 2

HCID 6063293-Nitro-5,6,7,8-tetrahydronaphthalen-2-olHCID 21226206Ethyl acetate hexane

Produkt 1

HCID 179106822-(5,6,7,8-Tetrahydro-3-nitro-2-naphthoxy)-propionic acid ethyl esterAusbeute 43 %

Versuchsvorschrift

5,6,7,8-Tetrahydro-3-nitro-2-naphthol is alkylated according to the general instructions that are mentioned in Example A) with D,L-2-bromopropionic acid ethyl ester. After column chromatography with hexane/ethyl acetate, the nitro compound is obtained in a yield of 43%.

Quellen und Nachweise

ORD-Eintrag
ord-4fb2c50462a64321b92c5075c8b84e67
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06365736B1

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