反应详情

In a mixture of 10 ml of glacial acetic acid with 1.25 ml of water, 2-(5,6,7,8-tetrahydro-3-nitro-2-naphthoxy)-propionic acid ethyl ester is dissolved and mixed in portions with 960 mg of iron powder. It is heated, cooled and poured onto water. The crystals are suctioned off and washed with water, dissolved again with ethyl acetate and washed with soda solution, the organic phase is washed with brine, dried with magnesium sulfate and concentrated by evaporation. 740 mg, yield 81%, results.

1. dissolutionis dissolved
2. temperatureIt is heated
3. temperaturecooled
4. additionpoured onto water
5. washwashed with water
6. dissolutiondissolved again with ethyl acetate
7. washwashed with soda solution
8. washthe organic phase is washed with brine
9. dry with materialdried with magnesium sulfate
10. concentrationconcentrated by evaporation
11. custom740 mg, yield 81%, results