Ammonia → HCID 22623130, compound

HRID 840384Notes

Reaction equation

HRID 840384 reaction equation
[CH3:1][CH:2]1[C:7](=S)[NH:6][C:5]2[CH:9]=[C:10]([CH2:13][N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)[CH:11]=[CH:12][C:4]=2[O:3]1.[NH3:19].C1(C)C=CC=CC=1>CO>[CH3:1][CH:2]1[CH:7]([NH2:19])[NH:6][C:5]2[CH:9]=[C:10]([CH2:13][N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)[CH:11]=[CH:12][C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 1140TolueneHCID 22623070HCID 22623070, compound

Product 1

HCID 22623130HCID 22623130, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

155 mg (0.597 mmol of (±)-2-methyl-3-thioxo-6-[(1-imidazolyl)-methyl]-3,4-dihydro-2H-1,4-benzoxazine is mixed with 10 ml of 7N NH3 in methanol, and it is stirred for 2.5 hours at room temperature. After 20 ml of toluene is added, the solvent is then spun off, and the desired compound is obtained quantitatively, melting point 152-156° C.

Sources & evidence

ORD record
ord-dfeb9fd623d545799df6e08fbaffdffa
Source dataset
uspto-grants-2002_04
Patent number
US06365736B1

Reaction notes

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