HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 22623130, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | HCID 22623070 | HCID 22623070 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22623130 | HCID 22623130 | — |
Reaction Steps
155 mg (0.597 mmol of (±)-2-methyl-3-thioxo-6-[(1-imidazolyl)-methyl]-3,4-dihydro-2H-1,4-benzoxazine is mixed with 10 ml of 7N NH3 in methanol, and it is stirred for 2.5 hours at room temperature. After 20 ml of toluene is added, the solvent is then spun off, and the desired compound is obtained quantitatively, melting point 152-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365736B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-dfeb9fd623d545799df6e08fbaffdffa |
| Source note | uspto-grants-2002_04 |