HCID 22622234, compound → HCID 22622343, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-phenylmethoxycarbonyl-4-[2-trifluoromethylthiophenyl]piperidine in trifluoroacetic acid was Cbz-deprotected by heating under reflux (at 80° C.) for 10 min. The mixture was concentrated to provide the product as an oil. 1H NMR (DMSO-d6) δ 7.69 (d, 1H), 7.59 (m, 1H), 7.50 (d, 1H), 7.32 (m, 1H), 3.32 (m, 2H), 3.00 (br d, 2H), 2.57 (m, 3H), 1.56 (m, 4H); MS m/z 262 (M+H).

Provenance & Evidence