HCID 22622234, compound → HCID 22622343, compound

HRID 840416Notes

Reaction equation

HRID 840416 reaction equation
C1(COC([N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[S:23][C:24]([F:27])([F:26])[F:25])[CH2:13][CH2:12]2)=O)C=CC=CC=1>FC(F)(F)C(O)=O>[F:27][C:24]([F:25])([F:26])[S:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1

Participants

3

Reactant 1

HCID 22622234HCID 22622234, compound

Product 1

HCID 22622343HCID 22622343, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
80 °C

Procedure

A solution of N-phenylmethoxycarbonyl-4-[2-trifluoromethylthiophenyl]piperidine in trifluoroacetic acid was Cbz-deprotected by heating under reflux (at 80° C.) for 10 min. The mixture was concentrated to provide the product as an oil. 1H NMR (DMSO-d6) δ 7.69 (d, 1H), 7.59 (m, 1H), 7.50 (d, 1H), 7.32 (m, 1H), 3.32 (m, 2H), 3.00 (br d, 2H), 2.57 (m, 3H), 1.56 (m, 4H); MS m/z 262 (M+H).

Workup

  1. temperatureby heating
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ada303a8f4f84572839146f30db97ae6
Source dataset
uspto-grants-2002_04
Patent number
US06365602B1

Reaction notes

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