5-Aminosalicylic Acid → Methyl Methacrylate

HRID 840435Notes

Reaction equation

HRID 840435 reaction equation
NC1C=C(C(O)=[O:8])C(O)=CC=1.[OH:12][CH:13]1[O:32][C@H:31]([CH2:33][OH:34])[C@@H:18]([O:19][C@@H:20]2[O:28][C@H:27]([CH2:29][OH:30])[C@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]2[OH:22])[C@H:16]([OH:17])[C@H:14]1[OH:15].[CH3:35][C:36]([C:38]([O:40][CH3:41])=[O:39])=[CH2:37].[Na+].[Cl-]>CO>[CH2:29]([OH:30])[C@H:27]1[O:28][C@@H:20]([O:19][C@H:18]2[C@H:16]([OH:17])[C@@:13]([OH:12])([CH2:14][OH:15])[O:32][C@@H:31]2[CH2:33][OH:34])[C@H:21]([OH:22])[C@@H:23]([OH:24])[C@H:25]1[OH:26].[OH2:8].[CH3:37][C:36]([C:38]([O:40][CH3:41])=[O:39])=[CH2:35]

Participants

7

Reactant 4

HCID 40755-Aminosalicylic AcidHCID 5234Sodium ChlorideHCID 6658Methyl MethacrylateHCID 440995(+)-Lactose

Product 2

HCID 6658Methyl MethacrylateHCID 66964417(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

5-Aminosalicylic acid (5-ASA), MgO for neutralization, and the additive were mixed in a mortar and made to prepare tablets. The tablets were coated with 11 wt % of a 10 w/v % methanol solution of Eudragit E100 by means of a Hicoater. Then tablets of lactulose were prepared and coated with 11 wt % of a 10 w/v % methanol solution of Eudragit RS100/triacetin (5/1). Each one of the tablets 1 and the tablets 2 and 200 mg of lactose were put in a #1 gelatin capsule. The capsule was coated first with a methanol dispersion of Eudragit RS100L/NaCl (particle size: 75 to 355 μm) (½) and then with 12 wt % of Eudragit L100/castor oil (5/1) to obtain the preparation of the present invention.

Workup

  1. customto prepare tablets

Sources & evidence

ORD record
ord-6b9a81c07dda4e67ab893d53f7328583
Source dataset
uspto-grants-2002_04
Patent number
US06368629B1

Reaction notes

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