反应详情

4.06 g (20 mmol) of 4-bromothioanisole and 75 ml of dichloromethane were introduced into a round-bottomed flask and 6.3 g (20 mmol) of meta-chloroperbenzoic acid were added. Stirring was carried out at room temperature for four hours and the reaction mixture was poured into water. The organic phase was separated by settling, dried over magnesium sulfate and evaporated. The residue obtained was purified by chromatography on a silica column eluted with a mixture of dichloromethane and heptane (70/30). After evaporating the solvents, 1.22 g (28%) of the expected sulfoxide, with a melting point of 80°-81° C., was recovered.

1. customThe organic phase was separated
2. dry with materialdried over magnesium sulfate
3. customevaporated
4. customThe residue obtained
5. customwas purified by chromatography on a silica column
6. washeluted with a mixture of dichloromethane and heptane (70/30)
7. customAfter evaporating the solvents, 1.22 g (28%) of the expected sulfoxide
8. customwith a melting point of 80°-81° C., was recovered