Methyl 5-bromothiophene-2-carboxylate → HCID 22619465, compound

HRID 840479Notes

Reaction equation

HRID 840479 reaction equation
[C:1]([CH:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)[OH:4])#[CH:2].Br[C:20]1[S:24][C:23]([C:25]([O:27][CH3:28])=[O:26])=[CH:22][CH:21]=1>>[OH:4][CH:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)[C:1]#[C:2][C:20]1[S:24][C:23]([C:25]([O:27][CH3:28])=[O:26])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 605713Methyl 5-bromothiophene-2-carboxylateHCID 11817362alpha-Ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol

Product 1

HCID 22619465HCID 22619465, compound

Procedure

Following the basic procedure of Example 32 by reacting 1.21 g (5 mmol) of α-ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol with 1.1 g (5 mmol) of methyl 5-bromo-2-thiophenecarboxylate, 371 mg (19%) of the expected methyl ester, with a melting point of 84°-85° C., were obtained.

Workup

  1. customwith a melting point of 84°-85° C., were obtained

Sources & evidence

ORD record
ord-40a0addc74cc4850b70fceece906986d
Source dataset
uspto-grants-2002_04
Patent number
US06368608B1

Reaction notes

Loading…