Methyl 4-iodobenzoate → HCID 22619469, compound

HRID 840485Notes

Reaction equation

HRID 840485 reaction equation
[C:1]([CH:3]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:16])([CH3:15])[CH2:10][CH2:11][S:12]2)=[CH:7][CH:6]=1)[OH:4])#[CH:2].I[C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:19]=1>>[OH:4][CH:3]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH3:16])([CH3:15])[CH2:10][CH2:11][S:12]2)=[CH:7][CH:6]=1)[C:1]#[C:2][C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 69273Methyl 4-iodobenzoateHCID 22619460HCID 22619460, compound

Product 1

HCID 22619469HCID 22619469, compoundYield 57.1%

Procedure

Following the basic procedure of Example 11(d), by reacting 2 g (8.6 mmol) of α-ethynyl-4,4-dimethyl-7-thiochromanmethanol with 2.25 g (8.6 mmol) of methyl 4-iodobenzoate, 1.8 g (57%) of the expected ester was obtained in the form of an yellow oil.

Sources & evidence

ORD record
ord-724795f5a0714f90b3def643a83e6f26
Source dataset
uspto-grants-2002_04
Patent number
US06368608B1

Reaction notes

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