反应详情

3-(2-Chloro-6-fluorophenyl)5-methylisoxaz-4-oyl chloride (7.9 g, 29.0 mmol) was added in portions to a stirred solution of ethyl-3-aminobenzoate (4.0 g, 29.0 mmol) and triethylamine (4.04 mL, 29.0 mmol) in dry dichloromethane at 0° C. Following the final addition, the mixture was allowed to warm to ambient temperature and stir for 1 hour. The solution was washed with 0.5M aqueous hydrochloric acid, brine, aqueous sodium bicarbonate, dried over magnesium sulfate, filtered, and evaporated to a foam which was used in subsequent reactions without further purification.

1. additionaddition
2. washThe solution was washed with 0.5M aqueous hydrochloric acid, brine, aqueous sodium bicarbonate
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated to a foam which
6. customwas used in subsequent reactions without further purification