(S)-methyl 2-hydroxy-3-phenylpropanoate → (2S)-2-[4-(2-benzyl-benzofuran-3-yl)-4''-methoxy-[1,1';3',1'']terphenyl-4'-yloxy]-3-phenyl-propionic acid

HRID 840643Notes

Reaction equation

HRID 840643 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:37]=[CH:36][CH:35]=[CH:34][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=3)[CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:39][C:40](=[O:50])[C@H:41]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)O>>[CH2:1]([C:8]1[O:9][C:10]2[CH:37]=[CH:36][CH:35]=[CH:34][C:11]=2[C:12]=1[C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][C@@H:41]([CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:40]([OH:50])=[O:39])=[C:21]([C:26]3[CH:27]=[CH:28][C:29]([O:32][CH3:33])=[CH:30][CH:31]=3)[CH:20]=2)=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5289077(S)-methyl 2-hydroxy-3-phenylpropanoateHCID 106724354-(2-Benzyl-benzofuran-3-yl)-4''-methoxy-[1,1';3',1'']terphenyl-4'-ol

Product 1

HCID 9830685(2S)-2-[4-(2-benzyl-benzofuran-3-yl)-4''-methoxy-[1,1';3',1'']terphenyl-4'-yloxy]-3-phenyl-propionic acid

Procedure

The title compound was prepared from 4-(2-benzyl-benzofuran-3-yl)-4″-methoxy-[1,1′;3′,1″]terphenyl-4′-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h , and was obtained as a white solid, mp 73-75° C.; MS m/e 629 (M−H)+;

Workup

  1. customwas obtained as a white solid, mp 73-75° C.

Sources & evidence

ORD record
ord-f37e8fc864304ccfbc40fc52c65b1ffc
Source dataset
uspto-grants-2002_04
Patent number
US06369072B2

Reaction notes

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