反应详情

温度

70 °C

37.6 g of sodium sulfite are dissolved in 500 ml of water and heated to 70° C. 62 g of 2-bromo-5-methylbenzenesulfonyl chloride are added in portions at this temperature. A 10N aqueous NaOH solution is simultaneously added dropwise here such that the pH of the solution is kept between pH=9 and pH=10. The mixture is stirred at 70° C. for 1.5 hours, and the solution is filtered off and then adjusted to pH=0 in an ice bath using a saturated aqueous HCI solution. It is subsequently stirred for 30 minutes, then the product is filtered off, washed with a little water and dried. 49.6 g of white crystals are obtained,

1. filtrationthe solution is filtered off
2. customadjusted to pH=0 in an ice bath
3. stirringIt is subsequently stirred for 30 minutes
4. filtrationthe product is filtered off
5. washwashed with a little water
6. customdried