Sodium Bicarbonate → HCID 131723162, compound

Participants

Reaction Steps

550 mg of {[benzyl(thiophene-2-sulfonyl)amino]methyl}-3′-(2-methoxy)ethoxy-biphenyl-2-sulfonic acid dimethylaminomethylenamide are refluxed for 1 h in 5 ml of EtOH and 5 ml of a saturated aqueous HCl solution. 100 ml of a 10% aqueous sodium hydrogencarbonate solution are added and the mixture is extracted 3 times with 100 ml of EA each time. It is dried over magnesium sulfate and the solvent is removed in vacuo. Chromatography on silica gel using MTB/DIP 1:1 yields 188 mg of a colorless oil.

Provenance & Evidence