Sodium Bicarbonate → HCID 131723162, compound

HRID 840652Notes

Reaction equation

HRID 840652 reaction equation
CN(C=[N:5][S:6]([C:9]1[C:10]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([O:38][CH2:39][CH2:40][O:41][CH3:42])[CH:33]=2)=[CH:11][CH:12]=[CH:13][C:14]=1[CH2:15][N:16]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[S:17]([C:20]1[S:21][CH:22]=[CH:23][CH:24]=1)(=[O:19])=[O:18])(=[O:8])=[O:7])C.C(=O)([O-])O.[Na+]>CCO.Cl>[CH2:25]([N:16]([CH2:15][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([O:38][CH2:39][CH2:40][O:41][CH3:42])[CH:33]=2)[C:9]=1[S:6]([NH2:5])(=[O:8])=[O:7])[S:17]([C:20]1[S:21][CH:22]=[CH:23][CH:24]=1)(=[O:18])=[O:19])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 131723163HCID 131723163, compound

Product 1

HCID 131723162HCID 131723162, compoundYield 37.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

550 mg of {[benzyl(thiophene-2-sulfonyl)amino]methyl}-3′-(2-methoxy)ethoxy-biphenyl-2-sulfonic acid dimethylaminomethylenamide are refluxed for 1 h in 5 ml of EtOH and 5 ml of a saturated aqueous HCl solution. 100 ml of a 10% aqueous sodium hydrogencarbonate solution are added and the mixture is extracted 3 times with 100 ml of EA each time. It is dried over magnesium sulfate and the solvent is removed in vacuo. Chromatography on silica gel using MTB/DIP 1:1 yields 188 mg of a colorless oil.

Workup

  1. extractionthe mixture is extracted 3 times with 100 ml of EA each time
  2. dry with materialIt is dried over magnesium sulfate
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-4d9986a9b9d1467ea8a5ffcb8a172738
Source dataset
uspto-grants-2002_04
Patent number
US06369069B1

Reaction notes

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