3,4-Dichlorophenyl isocyanate → 5-Methoxy-3-(4-(3,4-dichlorophenylaminocarbonylamino)-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one

HRID 840728Notes

Reaction equation

HRID 840728 reaction equation
[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([CH3:16])[CH:10]=2)[N:4]=1.[Cl:17][C:18]1[CH:19]=[C:20]([N:25]=[C:26]=[O:27])[CH:21]=[CH:22][C:23]=1[Cl:24]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[O:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:26]([NH:25][C:20]3[CH:21]=[CH:22][C:23]([Cl:24])=[C:18]([Cl:17])[CH:19]=3)=[O:27])=[C:11]([CH3:16])[CH:10]=2)[N:4]=1

Participants

4

Reactant 2

HCID 76073,4-Dichlorophenyl isocyanateHCID 98778575-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one

Product 1

HCID 699703415-Methoxy-3-(4-(3,4-dichlorophenylaminocarbonylamino)-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The latter compound was obtained by reacting 5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)oxadiazol-2-one with equimolar amounts of 3,4-dichlorophenyl isocyanate in toluene at 50° C.

Workup

  1. customThe latter compound was obtained
  2. customat 50° C.

Sources & evidence

ORD record
ord-0635da5948b94429b205f91722f74981
Source dataset
uspto-grants-2002_04
Patent number
US06369088B2

Reaction notes

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