反应详情

Acetic anhydride (62 mg) is added to a methylene chloride (3 ml) solution of 6-amino-1-(2-chlorobenzyl)-2-n-propylbenzimidazole (150 mg) (example 3) and triethylamine (61 mg) at room temperature, and the solution is stirred for one hour. After it is washed with water and dried, the solvent is removed through evaporation under reduced pressure. The residue is crystallized with ether, and 6-acetylamino-1-(2-chlorobenzyl)-2-n-propylbenzimidazole (143 mg) is obtained. 1H-NMR (CDCl3, δ): 1.00 (3H, t, J=7.5 Hz), 1.86 (2H, m), 2.17 (3H, s), 2.73 (2H, t, J=7.5 Hz), 5.39 (2H, s), 6.43 (1H, d, J=7.5 Hz), 6.98-7.11 (2H, m), 7.22 (1H, t, J=7.5 Hz), 7.45 (1H, d, J=7.5 Hz), 7.59 (1H, brs), 7.68 (1H, d, J=7.5 Hz), 7.84 (1H, d, J=1.5 Hz).

1. washAfter it is washed with water
2. customdried
3. customthe solvent is removed through evaporation under reduced pressure
4. customThe residue is crystallized with ether