3-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one → Methyl 6-methyl-6,7-dihydro-5H-benzocycloheptene-8-carboxylate

HRID 840981Notes

Reaction equation

HRID 840981 reaction equation
N[C:2]1C=CC2CCCCC(=O)C=2C=1.[CH3:14][S:15][C:16]1[CH:17]=[CH:18][C:19]2[CH2:25][CH2:24][CH2:23][C:22]([C:26]([O:28][CH3:29])=[O:27])=[CH:21][C:20]=2[CH:30]=1.CSC1C=CC2CCCCC(=O)C=2C=1>>[CH3:14][S:15][C:16]1[CH:17]=[CH:18][C:19]2[CH2:25][CH2:24][CH2:23][C:22]([C:26]([O:28][CH3:29])=[O:27])=[CH:21][C:20]=2[CH:30]=1.[CH3:2][CH:24]1[CH2:23][C:22]([C:26]([O:28][CH3:29])=[O:27])=[CH:21][C:20]2[CH:30]=[CH:16][CH:17]=[CH:18][C:19]=2[CH2:25]1

Participants

5

Reactant 3

HCID 2668073-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-oneHCID 226205033-methylthio-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-oneHCID 22620567Methyl 2-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate

Product 2

HCID 22620535Methyl 6-methyl-6,7-dihydro-5H-benzocycloheptene-8-carboxylateHCID 22620567Methyl 2-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate

Procedure

Methyl 2-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate was synthesized by carrying out reactions according to the methods described in Reference Example 1, (a) to (c), except for using the 3-methylthio-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one obtained in the above item (b).

Sources & evidence

ORD record
ord-c986fc94259648ca83bc5cfcf0a36a83
Source dataset
uspto-grants-2002_04
Patent number
US06369110B1

Reaction notes

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