20633-28-7 → HCID 22620527, compound

HRID 840988Notes

Reaction equation

HRID 840988 reaction equation
[CH3:1][C:2]([CH3:16])([CH2:7][C:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([OH:6])=[O:5].[H][H]>C(O)(=O)C.[C].[Pd]>[CH3:1][C:2]([CH3:16])([CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH2:3][C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 2262047820633-28-7HCID 178418361HCID 178418361, compound

Product 1

HCID 22620527HCID 22620527, compoundYield 89.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

3,3-Dimethyl-5-oxo-5-phenylpentanoic acid (17.0 g, 77.2 mmol) was subjected to hydrogen catalytic reduction in acetic acid (170 ml) by using 10% palladium-carbon as a catalyst. After completion of the reaction, the catalyst was filtered off and the solvent was distilled off under reduced pressure to obtain 14.2 g of 3,3-dimethyl-5-phenylpentanoic acid.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe catalyst was filtered off
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4f9a39995b6f4a988c7badb1a328a8f8
Source dataset
uspto-grants-2002_04
Patent number
US06369110B1

Reaction notes

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