Hydrochloric Acid → HCID 70169617, compound

HRID 840990Notes

Reaction equation

HRID 840990 reaction equation
[CH3:1][CH:2]([CH:4]([C:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5][CH2:6][C:7]([OH:9])=[O:8])[CH3:3].[H][H].Cl>[C].[Pd].C(O)(=O)C>[CH3:3][CH:2]([CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:5][CH2:6][C:7]([OH:9])=[O:8])[CH3:1]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 70170816HCID 70170816, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70169617HCID 70169617, compoundYield 86.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

4-(2-Propyl)-5-oxo-5-phenylpentanoic acid (5.50 g, 23.5 mmol) was subjected to hydrogen catalytic reduction at room temperature by the use of 10% palladium-carbon (0.6 g) as catalyst in a mixed solvent of acetic acid (60 ml) and 35% hydrochloric acid (3 ml). The catalyst was filtered off and the filtrate was concentrated under reduced pressure to obtain 4.49 g of 4-(2-propyl)-5-phenylpentanoic acid.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6a7fff5c42e44de89d6b9661c1ee25ab
Source dataset
uspto-grants-2002_04
Patent number
US06369110B1

Reaction notes

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