反应详情

5.1 g, 19.6 mmol 1-bromomethylfluorene dissolved in 50 ml THF was added dropwise to 0.24 g, 9.9 mmol Mg in 10 ml THF. After addition the Grignard was refluxed for 2 hrs, cooled and water/aqueaous HCl added. After work-up this afforded 1.5 g of CH2CH2(1-fluorenyl)2 as a beige powder. 1H NMR (CDCl3): δ 3.81 ppm (CH2), 3.14 ppm (CH2).

1. additionAfter addition the Grignard
2. temperaturewas refluxed for 2 hrs
3. temperaturecooled