反应详情

温度

50 °C

Magnesium (3.0 g) was stirred in methanol, carbon tetrachloride (0.5 ml) added and the mixture warmed at 50° C. until the metal had dissolved (1.5 hours). Tert-butyl 3-cyclopropyl-3-oxopropanoate (20.0 g) was then added dropwise and the mixture heated under reflux conditions for 1 hour. The solvent was evaporated and re-evaporated after addition of toluene to give tert-butyl 3-cyclopropyl-3-oxopropanoate magnesium salt (29.9 g) as a white solid, m.p. >300° C., IR max (C═O) 1520, 1540; (C—O) 1350 cm−1.

1. dissolutionhad dissolved (1.5 hours)
2. temperaturethe mixture heated under reflux conditions for 1 hour
3. customThe solvent was evaporated
4. customre-evaporated
5. additionafter addition of toluene